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Reimbursement of new pharmaceuticals up to now was based simply on registration data (efficacy, safety and quality parameters).
For tumour volume data, efficacy was quantified using the normalised mean difference summary statistic (Sena et al, 2010).
To maintain data efficacy and credibility, manuscript was reviewed and modified with each unit analysis along with the extracted implications using supplementary participant views and suggestions.
Efficacy analysis was performed on patients over 50 years of age with accurate and complete data (efficacy population), using a last observation carried forward imputation.
Unlike the Western data, efficacy and safety of PEG-IFN alfa-2a were similar to those of PEG-IFN alfa-2b in chronically HCV-infected Korean patients regardless of age, HCV viral load, and hepatic fibrosis.
A scientific rationale, evidence of blood brain barrier (BBB) penetration, adequate safety data, efficacy in animal models and/or preliminary efficacy data in humans are requirements to identify promising neuroprotective drugs in PD (Ravina et al. 2003).
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They would want to look at the data on efficacy, duration and safety in 2014, she said.
Phenotypic data on efficacy and toxicity were available.
In its first iteration, the bill would have conferred conditional approval to HCT/Ps that demonstrated clinical safety and some data supporting efficacy — essentially eliminating phase III trials.
Data on efficacy and safety of treatments in children with vitiligo are limited.
However, data on efficacy of adjuvant endocrine therapy regimens and histological subtypes are sparse.
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