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We analyzed the EPICOR methylation data (discovery phase, 425,498 CpGs) with the A-clustering algorithm [ 24] to identify clusters of two or more neighboring CpGs with correlated methylation levels.
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Because FIRE-pro does not use protein disorder data during the motif discovery phase, such data provides an opportunity to independently assess the validity of the motif predictions.
We next imputed classical HLA alleles using the dense SNP genotype data of the discovery phase subject set, using a published statistical methodology previously shown to impute HLA alleles from SNP data with 92 98% accuracy at the four-digit level.
After meta-analysis of these new data together with Discovery Phase and Replication Phase 1, seven SNPs showing evidence of associations with BE risk at Pmeta <5 × 10−6 were identified and genotyped in Replication Phase 3 samples (Table 1).
Mandatory data deposition in the public domain, such as into the Gene Expression Omnibus (GEO), increasingly allows the use of publicly available data for the biomarker discovery phase and the use of new patient samples for the validation phase.
The IATA protocol includes two phases: topology discovery phase and data transmission phase.
The approach also enhances the ability of researchers to use the metabolomic data collected from the biomarker discovery phase to gain insight into disease biology.
For WSR and PSR, they have no route discovery phase before sending data packets, so the delay is mainly due to propagation delay.
The information exchange during the discovery phase completely relays on UWB communication.
The data sets supporting the results for the discovery phase (NGRC dataset) were generated by our group and are publically available in the NCBI dbGaP repository, phs000196.v2.p1, (http://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi study_id=phs000196.v2.p1).cgi study_id=phs000196.v2.p1
In order to examine the 4 genome-wide significant BE + EAC SNPs and 83 other SNPs with P assoc < 10−4 in the BEACON/BEAGESS data, we performed association testing using AspECT Discovery Phase cases.
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