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In this data discontinuation dates were set externally e.g. from an involved physician.
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Data concerning discontinuation was number of patients who discontinued and continued treatment.
We assume that 40% of patients will discontinue treatment at 12 months based on Australian data on discontinuation of statins [ 21] and blood pressure-lowering drugs [ 22].
Data for discontinuation for reasons other than a mood episode were available from six studies (n = 1,085).
In addition, the previous meta-analysis did not include data on discontinuation for reasons other than a mood episode though differences between lithium and placebo/active comparator in this issue may bias the data on efficacy and vice versa.
First, the data on discontinuation of dialysis in this study came from the death notification form utilized by the USRDS.
Weibull survival curves were fitted to the data on discontinuation at 48 hours, preterm delivery at 48 hours, and at 7 days.
Two studies RTOG-85-31 RTOG-85-31 RTOG-85-31 271 patients with nodEST-3886ve prostate cancer reported data on discontinuation due to adverse events.
Sequencing data at discontinuation were available from 70/92 (76%) bosutinib and 55/72 (76%) imatinib patients, including 9/10 (90%) and 25/33 (76%) who discontinued because of progressive disease.
However, when compliance is measured by administrative data, the discontinuation rate was 68% for daily dosing and 56% for weekly dosing.
Interestingly, whereas sequence variations (mostly representing polymorphisms) detected before treatment initiation occurred at similar frequency in both treatment arms, these mutations appeared less often in bosutinib-treated [ n = 4 (6%)] versus imatinib-treated [ n = 10 (18%)] patients with sequencing data at discontinuation.
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