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Data custodians waived formal ethical review as the study was a methodological one using de-identified patient data.
In all cases, data custodians can provide additional information.
Because results are run against confidential data, they will be reviewed by the data custodians for disclosure concerns.
This requires determining the number of data custodians required to act on the hold request, and the amount of data affected thereby.
While these data are accessible to approved researchers through the standard ethical and data application processes, they are not publicly available and are maintained by the relevant government data custodians.
The authors also are grateful to the many data custodians who have been willing to share their data with OBIS, thus making possible this type of large-scale analysis.
Data custodians, extraction criteria and linkage methods are described elsewhere.
SLUs are usually located external to the data custodians and researchers.
The data custodians for the three non-public clinical data sets also approved this protocol.
Finally, researchers receive only health information and a linkage key from the data custodians.
Data custodians need to generalize their demographic information further for longitudinal data sets.
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