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HLA mismatch was defined as ⩾1 known allele mismatch in HLA class 1 and/or HLA class 2. Data censure was conducted on 30 November 2011.
The patient did not develop GvHD after DLI and was in CR for 97 months at the time of data censure.
All patients were treated with experimental allo-SCT and were not enrolled in ongoing prospective trials at the date of data censure.
At the time of data censure, 22 of 30 (73%) patients had died due to disease or due to treatment-related complications and 8 of 30 (27%) patients were alive in CR (median: 44 months; range: 2 119 months).
At data censure, 13 of 24 patients (54%) had relapsed, 3 (13%) patients had died due to complications in CR and 8 (33%) patients survived in CR (see above).
CD4 and VL laboratory results were available for all children who reached a 6 or 12 month endpoint, however no values were recorded for patients initiated in the 6 months prior to data censure.
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Date of data censuring was 30 November 2011.
At data censuring, 1 of 20 (5%) patients treated with RIC had died due to treatment-related complications, 10 (50%) had relapsed and died, 4 (20%) had not reached CR and died and 5 (25%) patients were surviving in CR.
For this analysis data were censured at 33 days for the placebo group, 44 days for the 14 day PQ group and 91 days for the 8 week PQ group (Table 3).
For the purpose of this analysis, data was censured at December 31 , 2003
Data were censured when follow-up ceased to be exclusively at our centre.
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