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Data calculation and analyses were conducted by a home-made program developed in MatLab (version 7.0; MathWorks, Natick, MA, USA).
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Data calculations and statistical analyses were performed using JMP 7.0 software (SAS Institute, Cary, NC).
JL performed mouse colony breeding and maintenance, treadmill running, tissue harvests, histological processing, staining and immunohistochemistry. DJG performed all QPCR analyses, data calculation and interpretation.
EMVA performed the biochemical analyses, data calculations and interpretation of results and helped to write the manuscript.
EL carried out all of the calculations, data processing and analyses, KS helped build datasets, and SJH designed experiments, drafted the manuscript and led the overall project.
ZMF authored code, did part of the calculations and analyses, contributed to the interpretation of the data and helped in drafting the manuscript.
TB initiated the work, authored code, did part of the calculations and analyses, contributed to the interpretation of the data and edited the manuscript.
Statistical analyses to evaluate the distribution of data, calculation of median and interquartile ranges were performed using GraphPad Prism (GraphPad Prism 4 Software, Inc., La Jolla, CA).
To complete all calculations and analyses in field units, Eqs.
Finally, data from the TCOD database together with its full provenance can be easily retrieved and imported back into AiiDA as input for further calculations and analyses (Reusability).
All calculations and analyses were carried out in R2.8.1.
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