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Studies of large administrative data bases, such as those analyzed in this study, can make a major contribution in this respect.
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Additionally, the CRED criteria are applied in the Literature Evaluation Tool of the Joint Research Centre (R. Carvalho, JRC, EU Commission, Ispra, Italy, personal communication), as well as in the reliability evaluation of ecotoxicity studies for data bases, such as the NORMAN EMPODAT (P. von der Ohe, Umweltbundesamt, Dessau, Germany, personal communication).
It must also be noted that administrative data bases, such as the one used, contain information on prescriptions as filled.
These data have been taken from the published literature, expert opinion, and government data bases such as the South African electronic TB (e-TB) register.
Extensive literature searches were performed using data bases such as the National Health Services Economic Evaluation Database, the Cochrane Database of Systematic Reviews, PsycINFO, Medline and Google Scholar.
Salient is the development of major data bases such as the 'Internet Brain Volume Database'[ 5] funded by 'The Human Brain Project' which attempts to archive this extensive volumetric data.
The advantages of using the ObstetriX™ database are the large number of variables available compared to the other state-wide routine data bases, such as the Perinatal Data Collection PDCC) and Admitted Patient Data Collection (APDC).
Bioinformatics tools incorporated in some of these databases allow the user to find additional information by cross reference to other data bases, such as the protein family of an allergen in Pfam, 29 the experimentally determined 3D structure in the Protein Data Bank, 3 gene sequences in GenBank, 30 or publications in PubMed.
MicroG appeals to some data bases, such as micro-cogeneration technologies and power consumption profiles that are also described.
This progress may be accelerated using programs that pull from industry and internet data bases, such as Zenith for predicting degradation products and ReadAcross for predicting a molecule's safety assessment liability.
The paper describes shortly an architecture of systems supporting the new class of services; this architecture extends beyond those systems which have initially been introduced by support of centralized data bases (such as web servers) and by federation components providing search and mapping functions which are necessary for the full exploitation of the capabilities of such services.
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