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All patients included were continuously and systematically evaluated online and, to verify the quality of the information, an in situ monitoring data assessment was performed in 15 % of patients randomly selected.
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All calculations for data assessment were performed using SPSS software.
All data assessments were performed independently by two independent review authors.
To fulfil the requirements of Norwegian legislation on processing of personal data, risk assessment was performed.
The process of study selection, data extraction, and quality assessment was performed by two reviewers independently.
Search strategy, data extraction, analysis and quality assessment was performed independently by authors and findings were confirmed within the team.
Data extraction and risk of bias assessment was performed according to the Cochrane Collaboration Guidelines [ 21].
For studies meeting the inclusion criteria, a risk of bias assessment was performed and data were extracted for synthesis.
Quality control assessment was performed comparing data of re-scored patients to their original counterparts through kappa coefficients and intraclass correlation coefficients, as appropriate.
The diagnostic assessment was performed without knowledge of genotype data.
Clinical assessment was performed retrospectively.
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