EUROCAT member registries collect data, ascertained from multiple sources, on all major structural congenital and chromosomal anomalies: the prevalence rate of all anomalies, excluding chromosomal anomalies, is 219.70 per 10000 births, and the rate of neural tube defects (NTDs: anencephalus and similar, spina bifida, encephalocele) is 9.32 per 10000 births (2007 2011).
Primary TKR data ascertained from the Australian Orthopaedic Association National Joint Replacement Registry.
The empirical data was ascertained on an Affymetrix 6.0 SNP chip and contained ~770, 000 SNPs across the 2, 770 Mb of the autosomal portion of the human genome that is 'SNP-mappable.' LD in data simulated under a neutral mutation-drift model is known to have much lower LD than is observed in human data [ 33, 35].
After probe placement in both cases, responsiveness to weakly acidic liquids (apple juice) was ascertained on the data recorder in real time.
Thus exposure data in this study were ascertained on all cases of cerebral palsy and a subset of all preterm infants enrolled in the longterm follow-up program.
Of the 117 686 cases of the eight cancer types in men recorded on any of the four data sources, 84 787 (72.0%) were ascertained on the GP record, 95 933 (81.5%) from the GP or linked mortality record, 111 990 (95.2%) from the GP, mortality or hospital record.
Presence of Howell-Jolly bodies was ascertained on laboratory tests.
*Data ascertained on 20/10/08 **Recorded for 77,674 (63.4%) ***Implying active care management and ongoing service contact A description of numbers of cases by primary (ICD-10) diagnosis, again from a search in October 2008, is provided in Table 4 for the 65% of all cases where this information was available.
Presence of 'micrographia' was ascertained on history.
Case data were ascertained from the population-based Northern Congenital Abnormality Survey and control data from national data on all births.
Information on patient characteristics and detailed angiographic and procedural data were ascertained at baseline.
