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Populations were resolved by principal component analysis of the SNP genotype data as implemented in EIGENSTRAT [22].

To further enrich the small databases, additional phytochemical-like formulae were generated in this study through in silico "derivatization" of KNApSAcK data, as implemented in LipidBank [27].

Integration of mouse model and cell line data as implemented in this study provides an innovative strategy that would be applicable to other cancer types for the discovery of circulating biomarkers.

A phylogenetic hypothesis for 18 waterfowl species (including two outgroup species from the basal waterfowl genus Dendrocygna) was estimated using Bayesian analysis of DNA sequence data, as implemented in MrBayes [47] and was used for all the phylogenetic analyses reported here.

We used Fisher's Exact Test for categorical data as implemented in the software package R [17].

We calculated the likelihood of each model given the data as implemented in the R-package LASER (version 2.2) [ 37].

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An alternative solution, and what forms the contribution described in this paper, is to use a non-relational database modality, the key-value pair data model, as implemented in NoSQL databases such as Google BigTable [ 8], a column-oriented storage system for structured data.

Bootstrap support was calculated by using 500 bootstrapped data replicates as implemented by SEQBOOT in PHYLIP.

Breeding values were obtained using a preconditioned conjugated gradient iteration on data algorithm as implemented in MiX99 [ 22].

Standard codon models were fitted to the data set as implemented in the codeml program from the PAML package.

Mean genetic distances within and between groups were computed using the p-distance and a pairwise deletion for the gaps/missing data treatment, as implemented in the Mega 5.10 software [ 27].

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