Therefore, the data has been analyzed using the available data and acknowledging the place of recruitment where possible.
Qin et al. [11] present challenges of Big data analytics and acknowledge the capabilities of MapReduce and RDBMS to solve these challenges.
Finally, we do agree with Heong et al on the need to collect data on current clinical practice and acknowledge the value of access to such data.
Caution is needed to both explicitly account for social pressure and acknowledge the limited data on safety and efficacy as we continue to discuss the use of drugs for CE, particularly in the clinical context.
The LODD project is actively exploring the exact conditions for modification and redistribution defined by the data providers, and acknowledges the limitations with respect to openness some of these datasets currently have.
We thank Dr. Kirsimari Aaltonen and R. N. Hanna Jäntti for their help with the patient data and gratefully acknowledge the Finnish, Icelandic, and Swedish Cancer Registry for the cancer data, and Professor Johannes Björnsson and his staff at the Department of Pathology Landspitali-University hospital for support and help with tissue samples.
However, our study is limited to the information in the available data, and we acknowledge the difficulty in operationalizing substance dependence; whether our operationalization of addiction to two or more substances, truly reflects the strength of the addiction phenotype is open to question.
In summary, considering all of the published data and acknowledging that the side-effect profiles for each drug are different, it would appear that at least for the moment, a clear case cannot be made for the preferential use of either irinotecan or oxaliplatin in first-line combinations (Punt, 2005).
Chase et al. [3], using data predominantly drawn from GenBank, and acknowledging the imperfect nature of these data, suggested the use of one or two, unspecified, plastid regions plus ITS as potentially useful plant barcodes.
Given these data and acknowledging that the pretest probability of different malignancies varies between centres, we recommend the following general diagnostic approach to the analysis of effusion samples that are sent for cytological analysis.
