For data analysis, each trial was grouped by the trial order in each session, and the grouped trials (i.e., 16 trials) in each condition determined by the session and trial order were named as follows: SE1, SE2, SE3 conditions in session A, WS1, WS2, SE3-B conditions in session B (See Fig. 1C).
Biostatistics faculty, students, and collaborators meet throughout the academic year to discuss statistical issues in areas of functional data analysis, clinical trials, and dose finding.
Prior to ERP data analysis, all trials containing eye artifacts were corrected using a blind component separation [50].
DOI: http://dx.doi.org/10.7554/eLife.01982.006 We first looked for evidence of sustained or sequentially timed neuronal activity in calcium fluorescence traces for individual cells (ΔF/F,'Materials and methods: Data analysis'), on trials following the CR learning peak.
Memory retention was assessed by focusing data analysis on test trial scores, i.e., by estimating the difference between the T group and the respective U group of each pair.
Both subjects and nurses were blinded to which trial arm children were allocated to, as were those responsible for data analysis; the trial code was broken after data analysis had been completed.
CB has been a consultant for Genentech, Roche, and has received Grant Support from Genentech, Roche HS drafted the manuscript, generated PK/PD data and performed data analysis and trial design.
Significant issues arose when the planned method of data analysis was trialled on the actual data collected: the voiding interval was often either missing or incorrectly documented and the schedule of proposed voiding times was either incomplete or incorrect.
Adaptive trial designs use interim data analysis to amend trials, and have been recognized for more than a decade as a way to increase trial efficiency, partly by the increased probability of demonstrating a drug effect if one exists.
Our results provide new clues to better design future trials with IVIG in sepsis and/or to improve data analysis from these trials.
