At the completion of baseline data acquisition, the trial coordinator provides the subject with a pathology request form, for which blood samples are taken within the first week of visit one.
Data acquisition during walking trials for all subjects was performed at the biomechanics laboratory at the University of Louisville.
YC was responsible for the design of the trial, data acquisition, data analysis and data interpretation.
EM assisted in trial development, day to day conduct of trial and data acquisition.
Figure 1 depicts a traditional paper-based data acquisition process for clinical trials, and Figure 2 is the flow chart for the proof-of-concept project.
SY day to day conduct of trial and data acquisition.
As primary author for this article, YC takes full responsibility for the design of the trial, for data acquisition, data analysis and data interpretation and the writing of the manuscript.
RP participated in the design of the study, supervised the trial and data acquisition process, RM performed the statistical analysis, interpreted the data and wrote this paper, ARG and XC analyzed and interpreted the data, AC participated in the design of the study, ELP conceived of the study, participated in its design, coordination and wrote this paper.
A subgroup of multiple visit patients at the main site was isolated using the criteria that their last visit fell within the time period of data acquisition for the multi center trial (N = 268 for the intermediate group and N = 132 for the heavy use group).
Data from the acquisition trials of Morris water maze were analyzed by a two-way mixed design ANOVA (strain x test day) separately for two different age groups.
