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Sensitivity analysis for uncertainty regarding data abstraction, bias assessment and included studies was performed.
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Data abstraction and risk of bias assessment will also be performed independently.
Trial selection, data abstraction and risk of bias assessment were performed in duplicate.
Two reviewers completed, in duplicate and independently, the study selection, data abstraction and risk of bias assessment.
The methods of the review are state of the art, and include independent duplicate study selection, data abstraction and risk of bias assessment.
To support these efforts at mitigating bias, data abstraction for all included studies was carried out by one independent researcher and verified by a second.
Moreover, there is inherent risk of either unreliable or biased data abstraction with this methodology.
Two reviewers will independently and in duplicate screen titles and abstracts, complete full text reviews to determine eligibility, and subsequently perform data abstraction and assess risk of bias of eligible trials.
For eligible studies, reviewers will perform data abstraction and assess risk of bias of eligible trials.
Standardized data abstraction forms and risk of bias forms were completed for all included studies.
172 173 The methods of these reviews may differ to varying degrees from the typical intervention review, for example regarding the literature search, data abstraction, assessment of risk of bias, and analysis methods.
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