Sentence examples for dat uptake from inspiring English sources

Our data confirm the association between DaT uptake in striata and motor symptoms, which is consistent with the hypothesis that motor symptoms in PD are related to dopaminergic nigrostriatal pathology [39].

As a consequence of DAT uptake, amphetamine produces competitive reuptake inhibition at the transporter.

Twenty-one patients showed decreased DAT uptake but normal MIBG uptake (Fig.  3, middle).

The relative DAT uptake decrease was faster in PD and PSP than in HC and MSA.

Nine patients showed normal DAT uptake and decreased MIBG uptake (Fig.  3, bottom).

There were no differences in DAT uptake reduction rates between PD and PSP.

MPP+ shows its selective toxicity to dopaminergic neurones through DAT-mediated uptake and DAT and DA receptors are expressed in SH-SY5Y cells (Presgraves et al. 2004) (Javitch et al. 1985).

In DAT-IMAs, uptake of MPP+ was prevented by the DAT blocker, GBR12909, while in OCT3-IMAs, MPP+ uptake was prevented by the OCT3 blocker, D22 (Supplementary Fig. S1A D).

The obtained tau values have previously been demonstrated to be related to the efficiency of DAT-mediated uptake of DA (Vmax/Km), and are sensitive to DAT inhibitors [16].

Table 1: Insulin at physiological concentrations (30 nM) increases Vmax for DAT-mediated uptake in striatal slices.

Increased evoked [DA]o was particularly surprising, given that this was accompanied by a significant increase in the maximal rate (Vmax) for DAT-mediated uptake in each subregion (Table 1), which would lead to a competing decrease in evoked [DA]o, as reported previously22,23.