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Mann-Whitney U test and Kruskal-Wallis test were used to assess differences in baseline characteristics, SERT BPND, and SERT to DAT ratio between different groups of subjects.
To touch base with previous imaging studies [ 47], we independently assessed the caudate/putamen DAT ratio.
These data confirm prior reports showing a higher caudate/putamen DAT ratio in nondemented PD compared with DLB [ 47].
We found identical results when we used the caudate/putamen DAT ratio: a higher ratio in the PD group than in the DLB (P = 0.01) and HCS (P < 0.0001) groups (see Additional file 1).
Similar(56)
However, also in this part of the striatum, SERT-to-DAT ratio was almost similar (Table 2) between the two groups.
Furthermore, to assess if a higher SERT-to-DAT ratio precedes the development of dyskinesias, we calculated the ratios of midbrain BPND versus BPND assessed in the caudate nucleus, putamen, and whole striatum.
Therefore, it is unlikely that a larger prospective study would prove that the SERT-to-DAT ratio in early stage drug-naïve PD patients correlates with the development of dyskinesias.
In contrast to this hypothesis, in the present study, the dyskinesias were not preceded by a higher SERT-to-DAT ratio in patients with dyskinesias compared to non-dyskinetic patients.
More specifically, since we performed a [123I]β-CIT scan at baseline, we cannot exclude the possibility that a change in SERT-to-DAT ratio occurs later in the course of the disease as a result of a slower progression of the degeneration of the serotonergic system compared to that of the dopaminergic system, particularly in patients that go on to develop dyskinesias.
In other words, if high SERT-to-DAT ratios precede the development of dyskinesias, one may postulate that SERT-to-DAT ratios will be highest in the most affected putamen.
Also, no significant differences between PDNDYS and PDDYS in SERT- to-DAT ratios were observed (Table 2).
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