Sentence examples for dat level from inspiring English sources

DAT expression is highly dynamic: the brain's DAT level adjusts to accommodate DA signaling, decreasing when DA release is low and increasing when DA release is high [5].

In order to determine the effects of DAT level on psychostimulant effects at the DAT, we used two models: DAT-tg and MPH self-administration.

DAT expression alters throughout the life span; first detectable in developing brain relatively late, starting from 32 gestation weeks, the DAT level reaches maximum during adolescence, and then gradually decreases at an estimated rate of 5 6% per decade [9].

Under this assumption, the individual variations in the DAT1 gene sequence can directly affect its epigenetic potential, so that we might construe large inter-individual differences in brain's DAT level as phenotypic manifestations of the combinatorial interplay of the DAT1 haplotype and epigenetic marks that jointly regulate the DAT.

Interestingly, photoperiod length can influence the DAT level in the brain of rats (Dulcis et al. 2013), thereby again connecting the dopaminergic system and the circadian rhythm (see "Circadian rhythm") with the pathophysiology of BD.

More specifically, cells might employ a rapid switch in transcriptional mode to achieve fast increase in DAT level, hence, rapid synthesis of DAT protein; whereas the production of longer, more stable transcripts prolongs translation time determining basal DAT's level.

In addition to increased cytoplasmic AMPH levels, higher DAT levels may also allow for augmented DAT coupling to VMAT-2 on synaptic vesicles, which together produces greatly augmented intravesicular AMPH concentrations and thereby greater vesicular depletion via AMPH-induced disruption of vesicular pH gradients.

However, we can not rule out the possibility that high DAT levels reflect a denser DA innervation, whereas low DAT could also reflect a decrease in striatal DA terminals, which has been shown in Parkinson's disease [73].

The diagnosis-dependent association of DAT concentration in the caudate and AC relative to DAT levels in the putamen led us to explore the relation of caudate and extrastriatal DAT concentration to cognitive function.

This indicates that, although potency of MPH at the DAT responds similarly to a releaser in regard to changes in DAT levels, it is not functioning as a releaser.

While cell culture studies have suggested that increasing DAT levels reduces the potency of blockers, but not releasers, in vivo studies have shown that increasing DAT levels increases the potency of releasers, but not blockers, to inhibit dopamine uptake.