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Dopaminergic lesions result in the loss of DAT terminals through degeneration, but there are additional losses in DAT function that result from a simultaneous reduction of DAT export, leading to its accumulation in the ER Golgi compartment.
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Although we did not detect mutations at the DAT-1 locus in vt25 and vt29, these mutations may still impact DA clearance, either through a functional impact on DAT-1 at DA terminals or through changes in the somatic export of DAT-1 protein.
Finally, the Mascot search results were exported into a DAT file, quantified using Mascot 2.3.01 with the following criterias: protein ratio type = median, minimum unique peptides = 1, peptide threshold type = at least homolog.
True dat.
Who dat?
"Spahk dat".
with dat.
Blau yn'e loft en dat betsjut dat.
Who says "Who Dat"?
Dat's proper wicked.
Lift dat bale.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com