Exact(6)
She just doesn't have "the danger gene," she explains to the camera.
The flanking genes of each DANGER gene were identified from the already annotated genome sequences (NCBI and Ensembl databases).
Approximately 25 Kbp upstream and downstream of each DANGER gene were retrieved from NCBI and Ensembl databases.
In the morphologically simple animal N. vectensis, DANGER gene sequences encode either a complete or a partial Mab-21 domain (Figure S5 and S8).
Although, we cannot formally exclude the possibility that the structure of some genes may have been mispredicted, most human and mouse DANGER gene structures are supported by cDNA sequences.
Overall, these observations indicate that TEs have contributed to the evolution of DANGER gene sequences and support the notion that recombination events among TEs probably contributed to the genetic variation of DANGER sequences during vertebrate evolution.
Similar(54)
From our data we cannot conclude how many DANGER gene-lineages existed in the bilaterian ancestor (Figure 6B and 6C).
Alternatively, the anthozoan DANGER gene-lineages could have persisted during metazoan evolution resulting in the vertebrate DANGER repertoire (Figure 6C).
The most conservative evolutionary scenario suggests that at least two DANGER gene-lineages existed in the common ancestor of anthozoa and bilateria.
Our phylogenetic analysis suggests that the common ancestor of vertebrates contained all three DANGER gene-lineages encoding localization signals (Figure 1A and Figure S2).
In conclusion, this evolutionary study of DANGER genes offers a view into the workshop of a busy evolutionary tinker.
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