Inhibition of Sp-1/Sp-3 significantly dampened the expression of Fas induced by F. tularensis subsp. novicida infection (Fig. 11B).
These data demonstrate that the therapeutic effect of H1R and H2R inhibitors appears to be more effective in the situation where H3R is functional (wild-type C57BL/6 mice) and can be interpreted at least in part by dampening the expression of inflammatory response-associated genes known to be critical for disease expression during CM.
DEHP dampened the expression of lactate dehydrogenase A and fibroblast growth factor 9, regulators of testis formation.
First, gain-of-function activation of FUS3 dampens the expression of a collection of ethylene-responsive genes, whereas a loss-of-function fus3 allele shows the opposite effect.
Loss of IL-1RI signalling also dampened the expression of select cytokines and chemokines, concomitant with significant reductions in neutrophil and macrophage infiltrates into the brain.
The significantly correlated expression patterns between host genes and miRNA target genes support the notion that intronic miRNA regulation improves host-associated biological functions by either tuning or dampening the expression of target genes.
Herein we show that activation of FUS3 after germination dampens the expression of genes involved in the biosynthesis and response to the plant hormone ethylene, whereas a loss-of-function fus3 mutant shows many phenotypes consistent with increased ethylene signaling.
On comparison of the Uygur medicine KJA intervention group with the physiological saline negative control group, Uygur medicine KJA can successfully treat UC rats by dampening the expression of TLR2, IL-1β, TGF-β1 and NF-κB.
Cytokinin dampens the expression of SCARECROW (SCR), which encodes a GRAS domain transcription factor that is necessary and sufficient to cell-autonomously instruct QC fate and is a key player relaying inputs from cytokinin and auxin signals (Moubayidin et al., 2013; Sabatini et al., 2003; Zhang et al., 2013).
Arabidopsis thaliana SNI1 (for Suppressor of NPR1, Inducible) is a negative regulator of SAR required to dampen the basal expression of PR genes.
