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By linking the output to a maximally phosphorylated state, competing dephosphorylation can effectively dampen output until a certain threshold input is reached.
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By binding to the so-called metabotropic glutamate receptor on glutamate-releasing nerve terminals, LY354740 dampens output of the neurotransmitter, but only when its levels get too high.
These results fit well to the observation that miRNAs dampen the output of preexisting mRNAs or optimize required protein output as it is proposed for metazoans [ 32].
Additionally, ENVOY can still dampen the output of the heterotrimeric G-protein cascade in terms of cAMP by alleviating its negative effect on PDE, which would decrease elevated cAMP levels despite positive effects of for example GNA3.
Taken as a whole, these works reveal that budget cuts have hardly dampened creative output.
The economic costs are also dampened because output, including services, can be produced using different combinations of resources.
We have also revealed that miRNA dampening the output of preexisting but unwanted transcripts to facilitate transition to new expression programs is a general mechanism for miRNA regulation of human gene expression.
In this study, we show that miR-130a inhibition dampens Hippo pathway output and reverses organ size enlargement and tumorigenesis induced by Hippo pathway deregulation or YAP activation.
Our results of higher and broader gene expression but fast mRNA decay rates also provide evidence that miRNA dampening of the output of preexisting transcripts facilitates a more rapid and robust transition to new expression programs.
The higher and broader gene expression but fast mRNA decay rates also suggests that miRNA dampening of the output of preexisting but unwanted transcripts to facilitate transition to new expression programs [ 32- 34] is a general mechanism for miRNA regulation of human gene expression.
Analysts believe the new increase in output will dampen crude oil prices.
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