The tumor can be targeted via active or passive strategies to ensure that (1) the anticancer drugs provoke apoptosis only to tumor cells without damaging the functions of the surrounding cells; (2) the drugs are delivered to the tumor cells without overdose concentrations and minimize the loss of activity (Moghimi et al. 2001).
In our previous work, S. sclerotiorum infection was shown to induce the over-accumulation of H2O2 in cucumber leaves due to inhibition of the activity of catalase, damaging the functions of photosystem I (PSI) and photosystem II (PSII) [ 16].
Since this compound was also found to be a uremic toxin damaging the functions of cells and proteins [ 40] its additional exogenous influx may accelerate the progression of uremia.
10, 11 SIFT and Poly Phen which predict the function of non-synonymous variants (http://genetics.bwh.harvard.edu/pph/), also revealed that the p.P19S mutation "probably" damages the function of the NDUFA1 protein (damaging score, 0.956).
"It's not that it damages the function of the teeth, but they can look unnatural".
The remaining 4,310 change the make up of the protein that the gene produces and 340 of these are predicted to damage the function of the gene.
Therefore, we expect that such mutations critically damage the function of corresponding proteins.
The change is predicted to damage the function of the enzyme by both Polyphen and SIFT, and analysis of over-expressed mutant protein in colon cancer cells HCT116 demonstrated decreased CYP24A1 and increased intracellular levels of 1,25(OH)2D3 [ 61].
Therefore, the mutations in LEP can possibly damage the function of leptin and disturb the metabolic balance in humans, which is directly responsible for severe obesity and other metabolic disorders.
Cystic fibrosis (it damages the function of the lungs that causes chronic cough).
