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Therefore, NB1011 therapy should kill tumor cells without severely damaging normal cells.
The common cancer treatment strategies like chemotherapy and radiotherapy are nonspecific and can trigger severe side effects by damaging normal cells.
In this study, we show that SNS01-T is preferentially taken up by malignant B cells, inhibits tumor growth in multiple animal models of B-cell cancers without damaging normal tissues, and synergizes with the current therapies bortezomib and lenalidomide to inhibit tumor progression.
Purpose: Postmastectomy irradiation (PMI) is a technically complex treatment requiring consideration of the primary tumor location, possible risk of internal mammary node involvement, varying chest wall thicknesses secondary to surgical defects or body habitus, and risk of damaging normal underlying structures.
An MCOW spokesperson declined to comment except to say that C-25 is "an organic compound" being studied to see if it can assist other drugs in killing cancer cells without damaging "normal" cells; the intellectual property rights are held jointly by MCOW and the University of Cincinnati.
Tissue-restricted expression is a desirable property for candidate genes as therapeutic targets in cancer, since their function could be inhibited without damaging normal tissues, their promoters could be used to enhance expression of cell death-inducing proteins in tumor cells, and tumor-specific proteins could serve as targets for immunotherapy or site-specific delivery of antitumor agents.
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When produced in excess, NO directly damages normal tissues and triggers inflammation.
Even so, non-specificity of cytotoxic agents is a major drawback and potential to damage normal tissues means that cure with chemotherapy is not often achieved.
One potential drawback, notes molecular geneticist Andreas Strasser of the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia, is that F16 may damage normal cells with high metabolic activity.
Excessive dose may damage normal tissue adjacent to tumor.
It is important to mention that selective COX-2 inhibitors do not damage normal gastric mucosa.
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