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At a remembrance ceremony at the library on January 6th, Watergate went unmentioned.For his critics, however, the crimes of Watergate were only the most damaging expression of a temperament monumentally ill-suited to the highest office.
Bilheimer, who had received an Academy Award nomination for The Cry of Reason, said that "the unrelenting, unpunished, and craven exploitation of millions of human beings for labor, sex, and hundreds of sub-categories thereof is simply the most appalling and damaging expression of so-called human civilization we have ever seen".
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Cell cycle can be directly arrested by DNA damaging drugs, expression of p53, p21, p16 or of constantly hyper-activated Ras/Rak/Akt [ 47- 50].
However, p.Asp95Asn is not predicted to be highly damaging as its expression in NBS cells seems to have a similar activity to the wild type protein [ 42].
We propose that enhancement of autophagic flux and mitochondrial recycling by hormetic compounds can diminish the expression of damaging reactive oxygen species and help to maintain mitochondria function, the normal lung fibroblast phenotype and promotion of a healthy lung.
And, most damaging, there were gratuitous expressions of scorn for international opinion and support.
Is Stern indicating that anti-Semitism is somehow less damaging than these other expressions of ignorance, bigotry and hatred?
To better understand the hypersensitivity of germline tumour cells to DNA-damaging drug, we analysed expression of various proteins that are involved in the drug sensitivity of cells.
Cells can senesce because of a response to persistent DNA damage from various endogenous or exogenous stresses, including replication-induced telomere shortening, DNA-damaging agents and high expression of certain oncogenes.
MMC is one of the range of DNA-damaging agents, which induces the expression of GADD34 (growth arrest and DNA damage –inducible protein) (review in Kanai et al, 2010).
The writer was forced into hiding, subsequent readings of the play were abandoned, and theatre's freedom of expression suffered a damaging blow.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com