Sentence examples for damaging drug from inspiring English sources

By that time baseball will know whether it has another damaging drug scandal on its hands.

Only when an immensely damaging drug emerges suddenly, as crystal meth did in some western states a few years ago, are concerted efforts made to communicate with older teenagers.Until recently the dominant approach was Drug Abuse Resistance Education (DARE), a programme developed in Los Angeles in 1983 and quickly exported to the rest of America.

Second, we assessed the induction of γ-H2AX after exposure to etoposide, a potent DNA damaging drug.

Zds2 confers resistance to the anticancer DNA damaging drug cisplatin (Burger et al. 2000), suppresses defects resulting from histone mutations (Ma et al. 1996), and suppresses mutations in the CDC20 gene required for chromosome segregation (Yu et al. 1996).

An alternative explanation for the absence of DNA reduplication in the presence of a DNA damaging drug could be that the DNA damage inflicted by the cytotoxic chemotherapeutic drugs inhibits DNA synthesis preventing the subsequent full re-replication of the genome.

These new data show that: a) Defects in the DNA damage signaling are observed in SETD2-depleted cells independently of the DNA damaging drug, as revealed by the impaired ATM activation.

Our results indicate the existence of HIF-1α specific mechanisms that regulate protein translation in response to different DNA damaging drugs.

It has been shown that BRCA1 inhibits DNA damaging drug-induced apoptosis by either transcriptionally activating cell cycle checkpoint genes [p21Cip1 and GADD45 (growth-arrest and DNA-damage-inducible protein 45)] or facilitating DNA damage repair processes by interacting with proteins involved in HR (e.g. RAD50/MRE11/NBS1) [ 171].

Conversely, overexpression of YY1 in the cancer cells suppresses FEN1 expression and sensitizes cancer cells to DNA damaging drugs.

We compared the sensitivity of cell lines to V158411 and a variety of DNA damaging drugs using data from the Genomics of Drug Sensitivity in Cancer data set (Release 4, [ 32]).

This contrasted with the effects of damaging drugs such as adriamycin (0.34 μM) or 5-fluorouracil (375 μM), which inhibited colony formation under these conditions, and suggested that resveratrol acts primarily through the reversible inhibition of cellular factors.