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This study opens up avenues for identifying new DNA damaging compounds from deep-sea bacteria.
DR5 is induced by DNA damaging compounds in malignant gliomas, including LN-229 [ 40].
Alkylating agents are a structurally diverse group of DNA damaging compounds which form adducts at ring nitrogen (N) and extracyclic oxygen (O) atoms of DNA bases [ 1].
Generally, platinum compounds are DNA damaging agents, and proliferating cancer cells are more prone to being killed by these DNA damaging compounds [8].
Furthermore, the actual degrading mechanism including the damaging compounds likely to present in the engine oil, hydraulic fluid and jet oil and their chemical reactions to Portland cement concrete (PCC) are presented.
A snippet of the virus's DNA, now embedded in the human genome, boosts production of damaging compounds in the brains of mice with a condition like MS, according to a report in the October issue of Nature Neuroscience.
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However, elevated levels of endogenous p53 did not result in up-regulation of p21 in the presence of the DNA damaging compound cisplatin (CDDP) (Figure 1A, right panel, compare lanes 2 and 4 to lanes 6 and 8), indicating that the response of the p53 pathway to DNA damage had been compromised [26], [38].
Moreover, the combined treatment of nutlin-3, together with the DNA damaging compound doxorubicin, boosted p53 levels and restored normal transcriptional activity.
Data obtained with the activation of the DNA damage checkpoint by etoposide provide an example of detectable modification of cell cycle suggesting that Capan-2 Fucci expressing spheroid models could be used to detect or to investigate the effect of a novel DNA damaging compound.
When garlic's structure is damaged, compounds such as diallyl disulfide and allyl methyl sulfide are released; these are ingested when we eat, and later released from our mouths as we breathe.
Many metabolites are prone to spontaneous and enzymatic side-reactions that form damaged compounds – a phenomenon known as metabolite damage [ 1- 3].
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CEO of Professional Science Editing for Scientists @ prosciediting.com