Sentence examples for damaging based on the from inspiring English sources
PolyPhen and PolyPhen-2 produce predictions (benign, possibly damaging, probably damaging) based on the rules regarding the SNPs effect on protein functional sites, the protein structure and the presence of the same peptide substitution in homologous sequences.
PolyPhen 2 (PPh2) [ 35] assigns to nonsynonymous SNPs a probability of being damaging based on the sequence, phylogenetic and structural information characterizing the amino acid substitution.
The second, p.Gly265Arg (c.793G>alsoalso a missense identified in a Belgian family, is predicted to be damaging, based on the SIFT and Polyphen2 analyses.
PolyPhen-2 calculates a Naive Bayes posterior probability that any mutation is damaging by the representation of a score ranging from 0 to 1 and predicts qualitative damage based on the model's false positive rate (benign, possibly damaging, or probably damaging).
American Express and Discover Financial quickly filed suit, seeking billions of dollars in damages based on the revenue they thought that they had lost.
They therefore conclude that estimates of damages based on the hypothesis and on share-price movements will be overstated.
Judge Walker refused to grant punitive damages based on the claim that the wiretapping under the National Security Agency program showed "reckless or callous indifference" to the plaintiffs' rights.
Though the average payment in Thursday's settlement is $525,000 per claimant, it will be up to Magistrate Judge William I. Garfinkel of United States District Court, as the mediator, to award damages based on the severity of each claim.
Michael Thornton, a senior vice president of DirecTV, said it was likely that the satellite service would seek damages "based on the economic advantage that Cablevision has in tiering YES".
But Justice Nye Perram said Dallas Buyers Club LLC could not claim for damages based on the uploads and downloads of the file on torrent sites because the idea was "so surreal as to not be taken seriously" and the number of copyright infringements would be "astronomical".
