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This is especially relevant for chemotherapy treatment, which is essentially a DNA damaging agent.
Also, the presence of extract protected yeast cells in a dose-dependent manner from DNA damaging agent [85].
Another DNA damaging agent is 5-FU.
The SOS chromotest assay is a bacterial test for detecting DNA damaging agent.
Instead, as might be predicted, biomarker responses appeared DNA damaging agent specific.
It is a well-characterized DNA damaging agent that induces the transitory delay of DNA replication.
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Cells that were treated with DNA-damaging agent alone received solvent (0.1% DMSO) instead of chemosensitizer.
PURPOSE: Voreloxin, a novel replication-dependent DNA-damaging agent, intercalates DNA and inhibits topoisomerase II.
These effects are similar to those caused by ionizing radiation (IR), which is a well-characterized DNA-damaging agent.
Our results were further confirmed when cells were treated with camptothecin, another DNA-damaging agent.
In accord with TEM images, calcineurin and crz1 mutants are hypersensitive to the membrane-damaging agent SDS at 37°.
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