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10, 11 SIFT and Poly Phen which predict the function of non-synonymous variants (http://genetics.bwh.harvard.edu/pph/), also revealed that the p.P19S mutation "probably" damages the function of the NDUFA1 protein (damaging score, 0.956).
"It's not that it damages the function of the teeth, but they can look unnatural".
Alzheimer's disease (AD) gradually damages the function and structure of particularly vulnerable brain areas, as those used for memory and cognition.
Cystic fibrosis (it damages the function of the lungs that causes chronic cough).
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Such privacy concerns lead to trust issues between entities, which clearly damages the functioning of the service and even blocks cooperation between entities with similar data sets.
Therefore, we expect that such mutations critically damage the function of corresponding proteins.
Unfortunately, making an opening in the cochlea can damage the function, which reduces the likelihood of obtaining reliable results.
High blood pressure can lead to substantial morbidity by damaging the function of critical organs including the brain, heart, blood vessels and kidney [ 3].
The change is predicted to damage the function of the enzyme by both Polyphen and SIFT, and analysis of over-expressed mutant protein in colon cancer cells HCT116 demonstrated decreased CYP24A1 and increased intracellular levels of 1,25(OH)2D3 [ 61].
Therefore, the mutations in LEP can possibly damage the function of leptin and disturb the metabolic balance in humans, which is directly responsible for severe obesity and other metabolic disorders.
High doses of nano-TiO2 significantly damaged the functions of liver and kidney and glucose and lipid metabolism, as showed in the blood biochemistry tests.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com