Muse cells are inherently resistant to cellular stress, and genetically resilient to DNA damage, supporting their application for the investigation of age-related and degenerative diseases.
We observed a decrease in the absolute number of monocytes with minocycline treatment with no further CNS damage, supporting the notion that monocyte expansion is required to drive disease.
Notably, erythrocyte counts did not decrease in dependency of other parameters indicative of liver damage (Supporting Fig. 2A-C).
MUSTN1 expression was also upregulated in correlation to exercise-induced muscle damage, supporting its possible involvement in muscle damage repair [ 93].
Further, kinetic analysis of serum ALT levels revealed that the lack of IL-17RA led to sustained protection from hepatocellular damage (Supporting Fig. 2L).
Oestrogens directly promote cellular proliferation in the lung and can induce direct DNA damage (supporting a role in lung cancer development).
As seen with HFD challenge, IL-17RA−/− mice exhibited increased body weight and weight gain, adiposity, hepatic weight, and hepatic triglyceride deposition, but were protected from glucose dysmetabolism and hepatocellular damage (Supporting Fig. 2).
Our results demonstrate that the PCI technique enhances the bleomycin effect under appropriate conditions, and importantly we show that PCI-bleomycin treatment leads to increased levels of DNA damage supporting that the observed effect is due to increased bleomycin uptake.
In an experiment in cells in vitro a low dose of arsenic had a protective effect against oxidative stress and DNA damage, supporting the hypothesis that low doses of arsenic could protect against cancer.
Crossbreeding heterozygous Cd2ap knockout mice with mice heterozygous (knockout) for synaptopodin or Fyn, which alone did not result in clinical kidney pathology, resulted in spontaneous proteinuria and FSGS-like glomerular damage supporting a role for CD2AP haploinsufficiency [ 60].
