Your English writing platform
Discover LudwigExact(7)
When cells in culture are exposed to ionizing radiation, even those not directly hit sustain damage to chromosomes.
Our observations are distinct from other studies wherein damage to chromosomes prior to anaphase resulted in mitotic arrest during metaphase [7] or delayed mitotic exit [6].
Using laser-mediated damage, we demonstrate that focal damage to chromosomes at regions other than the chromosome tips does not cause cells to arrest, with almost all cells proceeding through cytokinesis.
Masitinib also does not cause damage to chromosomes or the mitotic apparatus in mouse bone marrow cells following two daily administrations at 437.5, 875, or 1750 mg/kg/day, and it is not mutagenic in a mouse lymphoma assay (our unpublished results).
Damage to chromosomes is also manifested as breaks and fragments, which appears as micronuclei in the rapidly proliferating cells [ 43, 44].
It also showed less micronucleus formation in binucleate cells (MN/BN) after treatment with the venom of P. bistriata, indicating low induction of coarse damage to chromosomes.
Similar(53)
Such tests, however, have mysteriously failed to flag mutations in 20% to 30% of European women with a family history of breast cancer, even when their cancer could be linked to BRCA1 by damage to chromosome 17, BRCA1's home.
In this study, we demonstrate that laser-induced damage to chromosome tips (presumptive telomeres) in anaphase of Potorous tridactylis cells (PtK2) inhibits cytokinesis.
Loss of, or damage to, chromosome-associated histones is also implicated in the determination of lifespan in yeast, worms and fruit flies.
Plants treated with various phenols suffered profound damage to their chromosomes, changes in genes, and a striking number of mutations.
The advantages of STXM include less radiation damage to the chromosomes compared to electron microscopy and without alteration of chemical specificity due to the stains.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com