Excessive production of ROS results in oxidative stress causing aberrant cell signaling, damage to cellular components, and subsequent disease.
MPO generates reactive oxygen species which cause oxidative damage to cellular lipids and proteins.
The damage to cellular membranes (units/L) is selected as an endpoint.
Cadet, J., Douki, T., Ravanat, J. L. & Di Mascio, P. Sensitized formation of oxidatively generated damage to cellular DNA by UVA radiation.
Oxidative damage to cellular membranes plays an important role in the pathobiology of tissue injury.
Production of ROS causes oxidative damage to cellular components, eventually leading to cell death.
These reactive oxygen species can induce damage to cellular materials and apoptosis occurs.
Metal oxide nanoparticles induce ROS production and put the cells under oxidative stress causing damage to cellular components, i.e., lipids, proteins, and DNA [67 69].
Reactive oxygen and nitrogen species induced by chronic inflammation could cause damage to cellular deoxyribonucleic acid (DNA), contributing to malignant cell transformation [20].
ROS typically includes the superoxide radical (O2−), hydrogen peroxide (H2O2), and hydroxyl radical (OH), which cause damage to cellular components, including DNA and proteins [105,106].
Consequently, organisms contain a complex network of antioxidant metabolites and enzymes that work together to prevent oxidative damage to cellular components such as DNA, proteins and lipids.
