Sentence examples for damage the function of from inspiring English sources

Therefore, we expect that such mutations critically damage the function of corresponding proteins.

Therefore, the mutations in LEP can possibly damage the function of leptin and disturb the metabolic balance in humans, which is directly responsible for severe obesity and other metabolic disorders.

The change is predicted to damage the function of the enzyme by both Polyphen and SIFT, and analysis of over-expressed mutant protein in colon cancer cells HCT116 demonstrated decreased CYP24A1 and increased intracellular levels of 1,25(OH)2D3 [ 61].

10, 11 SIFT and Poly Phen which predict the function of non-synonymous variants (http://genetics.bwh.harvard.edu/pph/), also revealed that the p.P19S mutation "probably" damages the function of the NDUFA1 protein (damaging score, 0.956).

"It's not that it damages the function of the teeth, but they can look unnatural".

High blood pressure can lead to substantial morbidity by damaging the function of critical organs including the brain, heart, blood vessels and kidney [ 3].

Cystic fibrosis (it damages the function of the lungs that causes chronic cough).

Besides, the catalyst is susceptible to premium fuel with low levels of lead (Pb) which results in the damage of the function of the catalyst due to blockage in the honeycomb Catalytic Converter.

This type of damage affects the function of brain networks and is often associated with poor clinical outcome (Sharp et al., 2014).

Recent reports have implicated the ECS in remote damage, but the function of the ECS in supraspinal structures after SCI has not been examined.

In DNA damage response, the function of hnRNP K in p53 activation has been reported to be modulated by sumoylation, which enables the protein to function as p53 cofactor or prevents HDM2-dependent ubiquitination and proteasomal degradation of hnRNP K.