Sentence examples for damage the checkpoint from inspiring English sources

Depending on the timing of DNA damage, the checkpoint arrests the cell cycle at G1/S, S, or G2/M phases [6].

As is the case for UV-induced damage, the checkpoint proficiency exhibited by the Chk1D469G allele translates into better survival for the strain in response to CPT treatment (Fig. 6C).

In response to DNA damage, the checkpoint kinases phosphorylate CDC25 phosphatases, resulting in CDC25 inactivation through either ubiquitin-mediated degradation or cytoplasmic sequestration.

Our results provide insight into the diverse mechanisms that link DNA damage and the checkpoint signaling pathway.

Throughout the day today, East German guards worked to repair the damage at the checkpoint, a main crossing point between East Berlin and West Berlin.

To avoid this scenario during DNA damage stress, the checkpoint protein Mrc1 is phosphorylated in a Mec1-dependent manner.

The DNA damage checkpoint, the first pathway known to be activated in response to DNA damage, is a mechanism by which the cell cycle is temporarily arrested to allow DNA repair.

The damage checkpoint once recruited may participate in the choice of repair pathways.

Collectively, these recent studies suggest a "multi-brake" model of the G2/M DNA damage checkpoint, in which the checkpoint targets not only Cdk1, but also several other mitotic kinases, and like that of Cdk1, inhibition of these non-Cdk kinases is essential for activation and maintenance of the DNA damage checkpoint.

Activation of the DNA damage checkpoint allows the cell to successfully repair DNA damage.

Therefore, it is possible that, as the DNA damage checkpoint weakens, the kinase may overcome the arrest.