Your English writing platform
Discover LudwigExact(6)
Indeed, most studies have demonstrated that the PPP is coordinately reprogrammed in response to both oxidative and genomic damage stresses (Fig. 4).
Moreover, HDAC inhibitor showed selective synergy with nucleoside analog-induced DNA damage to inhibit cell proliferation, but showed no such effect with other DNA damage stresses such as γ-ray and UV, etoposide or cisplatin.
The general downregulation of miR-185 by ionizing radiation suggests that miR-185 may have an important regulatory role in cellular responses to DNA damage stresses.
Thus, unlike cell death induced by other high-dose DNA damage stresses, which induce ROS-dependent cell death, it was suggested that gliomas do not produce ROS even after a maximum clinical dose of CB irradiation, which may be related to the refractory nature against standard radiotherapy.
Also, SMC1, as a subunit of cohesion, is not only activates DNA repair but also facilitates the recruitment of checkpoint proteins, which activates the intra-S and G2/M checkpoints, indicating that the activation of SMC1 after DNA damage stresses is required for the G2/M checkpoint, as well for intra-S checkpoint.
Reactive oxygen species are one of the common endogenous DNA damage stresses (Vilenchik and Knudson, 2003), whereas STAT3 is constitutively present in the mitochondria (Wegrzyn et al, 2009; Boengler et al, 2010), which is one of the major sources of ROS in the cell (Turrens, 2003).
Similar(54)
Mutation could also be a consequence of locally induced DNA-damaging stresses within microcolonies.
Hormesis B causes stresses including damaging stresses.
If aging is caused by damage, then damaging stresses would accelerate aging.
Ku70-deficient cells have increased sensitivities to apoptotic stresses that are not limited to DNA-damaging stresses, consistent with its anti-apoptotic activity.
As previously discussed, the man is damaged, stressed, and wants to get the hell out of dodge and after all he's seen?
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com