Shichita, T. et al. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1.
Cordeiro, J. O. V. & Jacinto, A. N. The role of transcription-independent damage signals in the initiation of epithelial wound healing.
It appears that many physiological and damage signals activate the cell death machinery by inhibiting the pro-survival Bcl-2 proteins.
Finally, increased p53 expression suggests that it may target the mitochondrial pathway for inducing apoptosis in response to DNA damage signals.
Taken together, our study identifies a novel p53 modification, demonstrates a new effector function for the 53BP1 tandem Tudor domain, and provides insight into how DNA damage signals are transduced to stabilize p53.
Effector responses are initiated by damage signals such as reactive oxygen species signaling from epithelial cells and recognized by cell surface receptors on hemocytes (Baxter et al., 2017).
Neutrophils are of critical importance in MOD, neutrophil influx being a hallmark of ALI and their inappropriate activation leading to tissue damage signals [167].
DNApK activation occurs in response to DNA damage signals [23], [24].
Telomere deprotection is known to induce DNA damage signals [5], [12].
On the other hand, Rfx1 recruits Tup1-Ssn6 to DNA damage inducible genes to repress transcription in the absence of DNA damage signals [35].
ATM is known to play a key regulatory role in DNA repair by transducing the DNA damage signals to cell cycle checkpoints and apoptosis [1], [3].
