Sentence examples for damage signalling from inspiring English sources

25 27 This may suggest a common pathogenic mechanism in AGS involving DNA damage signalling.

ATM/Tel1 and ATR/Mec1 regulate the DNA damage signalling response.

ccRCC cells with inactivating mutations on SETD2 show impaired DNA damage signalling.

The blood samples were kept at 37 °C for 30 min to allow DNA damage signalling.

For therapeutic purposes DNA damage signalling processes are induced to induce apoptosis in tumour cells.

In conjunction with several telomere-binding proteins, telomeres protect chromosomes from recognition and degradation by DNA damage signalling pathways [ 6].

Fibroblasts and induced pluripotent stem (iPS) cells derived from HGPS patients show persistent DNA damage signalling and premature senescence.

These encompass enhanced chromosome breakage, telomere shortening, telomere dysfunction, accumulation of DNA damage and increased DNA damage signalling [ 22– 28].

The stabilization of the complex in presenescent VSMCs suggested that it may have a role in DNA damage signalling.

The shelterin component TRF2 plays a key role in telomere protection and prevents ATM-dependent DNA damage signalling at telomeres.

Concomitantly, we observed the phosphorylation of histone variant H2AX, γ-H2AX, which indicates putative telomere-initiated DNA-damage signalling.