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Maréchal A, Zou L. DNA damage sensing by the ATM and ATR kinases.
Ahmed, A. S. & Ramanujan, R. V. Magnetic field triggered multicycle damage sensing and self healing.
Maréchal, A. & Zou, L. DNA damage sensing by the ATM and ATR Kinases.
Marechal, A. & Zou, L. DNA damage sensing by the ATM and ATR kinases.
Expression of key genes involved in DNA damage sensing, repair, cell-cycle arrest and apoptosis was analyzed.
We next asked whether interfering with nucleo-cytoplasmic shuttling of FUS is sufficient to impair DNA damage sensing by FUS.
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Atm (−3.1-fold, q = 7e−5), a DNA damage sensing-enzyme that, when reduced leads to increased Xbp1 splicing (He et al., 2009), was downregulated with food deprivation.
Moreover, TLR2/CAPs axis exemplifies a novel oxidative-damage sensing mechanism aimed to promote vascularization.
These experiments directly involved the DNA-damage sensing enzyme DNA-PKcs in setting the apoptotic threshold in RA T cells.
PARP-1 consists of three conserved, major domains, a NH2-terminal DNA-damage sensing and binding domain containing three zinc fingers, an automodification domain, and a C-terminal catalytic domain.
ATM orchestrates HDR by interacting with the DNA-damage sensing MRE11-Rad50-NBS1 (MRN) comphosphorylatesylates multiple target molecules and activates cell cycle checkpoints to arrest the cell cycle and allow for fixing of the DNA (Lavin, 2007).
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