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The experiments are designed to shed more light onto specific parameters that are currently proposed to govern damage search and recognition by endonucleases III.
Comparisons of these models with biochemical nicking data revealed significant changes in the damage search mechanisms between wild-type pdgs and most of the mutant enzymes.
Plasma citrulline concentration, plasma I-FABP (biomarker of enterocyte damage), search for sepsis, results of bacterial sample, and usual clinical and biological variables were collected.
The implications of these findings to the damage search process in human cells are discussed.
These findings provide key insights into how the ionic environment in cells influences the DNA damage search pathway.
In this study, we use CC theory to understand how each transient complex on the damage search pathway of human uracil DNA glycosylase (hUNG) responds to changes in salt concentration.
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At each step along this coordinate, the enzyme must form DNA interactions that are highly specialized for either rapid damage searching or catalysis.
'Media damaged search for Madeleine Thee father of Madeleine McCann has said the media coverage of his daughter's disappearance may have permanently damaged the possibility of finding her.
As the fire that ravaged Fort McMurray finally moves past the city, and the province tallies the heartbreaking damage, a search will begin to discover the source of the destruction.
The Belgian court copyright infringement ruling against Google News will not ultimately damage the search engine service, but it will bring the company to the negotiating table with publishers who are concerned about how their content is being used online.
Many right to be forgotten cases concerned people who had created a profile on an online community which years later they had forgotten existed, had lost their log-in details and worried about a profile that "no longer reflected reality or could damage their search for work".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com