Exact(10)
A consensus opinion is that artemisinin-related compounds exert their antitumor activities through oxidative damage reactions.
The application of hold times in TMF-experiments leads to different damage reactions than during LCF loading.
Free radical-induced oxidative damage reactions, and membrane lipid peroxidation (LP), in particular, are among the best validated secondary injury mechanisms in preclinical traumatic brain injury (TBI) models.
Although historically overlooked and underappreciated, such metabolite damage reactions are now known to occur throughout metabolism and to generate (formerly enigmatic) peaks detected in metabolomics datasets.
We then review how metabolite damage reactions can be predicted, how repair reactions can be prospected, and how metabolite damage and repair can be built into genome-scale metabolic models.
Metabolite damage and repair are highly relevant to engineered pathway design: metabolite damage reactions can reduce flux rates and product yields, and repair enzymes can provide robust, host-independent solutions.
Similar(50)
DNA damage response reactions include removal of damaged DNA and restoration of the continuity of the DNA structure; activation of a DNA damage checkpoint, which arrests cell cycle progression in order to allow repair and transmission of damaged or incompletely replicated chromosomes; or apoptosis, which eliminates seriously damaged cells.
We set the rate law for DNA damage reaction so that it gradually increased over time.
More mechanistic models that explicitly represent ROS, the damage reaction with a protein (citrate synthase) and repair reaction with a heat shock protein (Hsp90) have been presented [ 39].
Indeed they seem to be essential to trigger gene expression required to prepare an adequate damage reaction in the surrounding tissues and organs.
SOD out-competes damaging reactions of superoxide, protects the cell from superoxide toxicity, and is widely used in scientific research and clinical practice [ 23, 24].
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