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Risk assessment in environmental genetic toxicology requires assays that determine effective levels of DNA damage of producing malignancy.
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Risk assessment in relation to chemical carcinogenesis requires assays that determine effective levels of DNA damage for producing malignancy.
Any case, the stresses in the colon wall never reach dangerous values capable of producing damage in the tissue.
Heterogeneity in both mechanical and hydraulic properties evolves from an initially random distribution of damage to produce localized failure and fluid transmission.
Rezulin was approved because of its life-saving potential for patients with severe diabetes, and it was known at the time that it presented a risk of producing liver damage.
These tornadoes are usually weak and short-lived, but still capable of producing significant damage.
The Ames test is based on a short-term bacterial reverse mutation assay aimed at detecting ranges of chemical substances capable of producing genetic damage with resultant gene mutations.
Both mutagen exposure (e.g., tobacco and sun) and changes in DNA repair systems are capable of producing DNA damage that results in major mutational signatures in cancer genomes.
Therapeutic doses of acetaminophen have the potential of producing liver damage if they are associated with circumstances that enhance the activity of the P-450 system leading to increased production of toxic metabolite, or that interfere with the protective mechanism by depleting the available glu-tathione.
Such an approach is much more economical than the typical "reactive" approach of deliberately injecting incompatible seawater, and then endlessly, and in most cases unsuccessfully, remediating sulfate scale damages over the life time of producing wells.
Even a severely damaged kidney may be capable of producing sufficient urine volume to prevent salt and water overload and avoid the need for UF.
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CEO of Professional Science Editing for Scientists @ prosciediting.com