Consequently, individual differences in processing of DNA damage could be of importance for transformation of the inflammatory changes of the biliary tree into cancer.
While microenvironmental damage may be of importance in the induction of hematopoietic failure, the primary target in leukemogenesis is likely to be the stem cell.
Nor will it deal with heat damage, which is also of importance.
A clue to the molecular factors involved came from a recent report showing that activation or inhibition of the DNA damage sensor ATM is of importance [ 58].
Unfortunately we do not have radiographic joint damage data, which are of importance for assessing long-term outcomes in patients with RA.
Diagonal propagation of damage shows the importance of shear failure criteria introduced in the erosion algorithm described above in Sect.
Therefore, these modes of damage highlight the importance of investigating and understanding their initiation and evolution in composite laminates with the aim to select lay-up configurations for better damage resistance and tolerance.
Although they have generally been concerned with the specific activities and knowledge domains related to conservation processes (such as cataloguing or monument damage), the importance of dealing with them in an integrated way is often neglected.
A sensitivity analysis showed that the damage parameters have varying degrees of importance.
However, it is also true that the used unloading reloading path does not account for the cyclic damage of concrete, but the importance of this effect on the hysteretic behavior of RC beams is beyond the scope of this paper.
