The continuous gonadotropin overstimulation of Leydig cells, together with a negative paracrine action of macrophages, could result in the damage of steroidogenesis and deficit of testosterone in situ.
It has been speculated that the continuous gonadotropin stimulation of Leydig cells, together with the negative paracrine action of macrophages on these testosterone producing cells, could result in the damage of steroidogenesis and deficit of testosterone in situ.
Observations of damage and deficits in the cholinergic system provided the rationale for the development of AChEIs, which inhibit the hydrolysis of acetylcholine.
Our observation that treatment with edaravone reduced the neuronal damage of CA1 region and improved neurological deficits in rats subjected to 10 min global cerebral ischemia is in agreement with a previous study where edaravone effectively alleviated brain injury and improved the neurological function after focal cerebral ischemia-reperfusion injury (Kikuchi et al., 2009).
Neuronal replacement may be particularly useful in cervical SCI, where loss of motor neurons at the level of damage produce specific deficits, e.g. decreased triceps control.
A cerebrovascular accident is defined by a sudden neurological deficit of vascular origin, as the damage of brain parenchyma arises from infarction (ischemic stroke) or bleeding (hemorrhagic stroke).
In acquired prosopagnosia, behavioral heterogeneity has been mostly explained by differences in the extent and location of the brain damage causing the deficit [5] [7], [49].
Diabetic nephropathy may be a disease of acquired MtDNA damage and bioenergetic deficit.
For example, a study of 270 patients with unilateral brain damage revealed all possible combinations of deficits associated with the lesioned hemisphere, with some showing deficits in both verbal and spatial function, some in verbal or spatial function alone.
Semantic errors were most strongly associated with left ATL damage whereas deficits on tests of verbal and non-verbal semantic recognition were most strongly associated with damage to deep white matter underlying the frontal lobe at the confluence of multiple tracts, including the inferior fronto-occipital fasciculus, the uncinate fasciculus, and the anterior thalamic radiations.
