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Cancer, in 3 Forms Dr. James Spencer, a dermatologist at Mount Sinai Hospital in Manhattan, calls ultraviolet radiation a complete carcinogen because it causes cancer in three ways: it directly damages DNA; it causes the release of free radicals, which damage molecules in cells; and it depresses the immune system so the body cannot defend itself.
However, the primary photochemical effects should not directly damage molecules that are delivered into the cell after illumination.
UV radiation can also damage molecules through its capacity to initiate uncontrolled free radical reactions, in most cases involving reactive oxygen species (ROS).
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tissue damage molecule.
By definition, the syndrome called sepsis implies a systemic inflammation, which changes the blood content with activated immune cells, release of mediators and hormones and presence of pathogen-related molecule (PAMPs) or tissue damage molecule (DAMPs).
The glutathione transferase family is part of an enzyme class that scavenges free radicals (reactive oxygen species supposed to damage molecule) created by oxidative stress.
Notably lacking from the biological processes modulated by DNA repair intermediates is that of the protein degradation machinery (e.g. 26S proteasome) which is robustly induced upon exposure to exogenous DNA damaging agents; this suggests that the trigger for upregulating the proteasome emanates from damaged molecules other than DNA, most likely from damaged proteins.
In nature, these act to neutralise damaging molecules created by ultraviolet light.
In the body, they do the same job – they stabilise damaging molecules on everything from cell membranes to the gut lining and blood vessels.
The resulting cells had impaired energy production, reflected by their high production of oxygen free radicals, damaging molecules generated when energy-generating processes don't run to completion.
But some clinical trials have suggested that such antioxidants, which sop up DNA-damaging molecules called free radicals, have the opposite effect and raise cancer risk in certain people.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com