Exact(15)
Clustered DNA damages are defined as two or more closely located DNA damage lesions that may be present within a few helical turns of the DNA double strand.
The processing of abasic site DNA damage lesions in extracellular DNA in the presence of engineered carbon nanomaterials (CNMs) is demonstrated.
The concept of targeting repair DNA stems from the central dogma underpinning radiotherapy, which is to induce complex DNA damage lesions which are difficult to repair resulting in cell death.
It has been reported that the C-terminal region of Chk1 may activate the checkpoint in response to distinct DNA damage lesions [28], [31].
Another nine diploid deletion strains predicted as being DOX sensitive showed little or no sensitivity to DOX but were sensitive to HU and/or MMS indicating that our diploid specific genes interact with other damage repair modules not required for the spectrum of DNA damage lesions induced by DOX.
PHRF1 quickly localizes to DNA damage lesions upon genotoxic insults.
Similar(45)
7,8-Dihydro-8-oxoguanine (oxoG), the predominant oxidative DNA damage lesion, is processed differently by high-fidelity and Y-family lesion bypass polymerases.
Around active NMO lesions AQP4 may selectively be lost in the absence of aquaporin 1 (AQP1) loss or other structural damage (lesion type 4).
Taking care not to damage lesion area, the teeth were reduced in size (both breadthwise and lengthwise) to better fit the SEM stub.
After the very acute phase of ischaemic and metabolic failure and damage, lesion growth into the penumbra may persist for hours or even days (Heiss et al., 1994).
The alternative "gap-filling" TLS model involves reinitiation of replication downstream from the damage lesion, resulting in a single-strand gap that is filled by one of the TLS polymerases.
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