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The possible assocation between YKL-40 and vascular damage is supported by the finding of an independent association between elevated circulating YKL-40 levels and increasing levels of albuminuria in T1D patients [8].
The role of ROS in the exercise-induced damage is supported by many studies.
Vacuolar damage is supported by experiments presented here showing that IpaB-containing vacuoles release fluorescent markers.
In higher plants, 2CP stability against oxidative damage is supported by accumulation of high protein amounts [ 30]. 2CP is assumed to be an ancient, stable peroxidase which is expressed prior to activation of APx in young tissues [ 82].
A role for UCP2 and UCP3 in attenuating superoxide production by the electron transport chain to protecting against oxidative damage is supported by the increased cellular production of ROS in UCP2 knockout mice [ 14] and the increased mitochondrial oxidative damage in mice underexpressing UCP3 [ 15].
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The negative effects induced by oxidative stress and oxidative damages are supported by the histochemical detection of the increase in the presence of ROS and oxidised proteins and by the tissue concentration of TBARS [ 48].
The experimentally observed phenomenology of the damage processes is supported by findings from simulation studies.
Specifically, such damage evolution is supported by experimental microscopic observations for short glass fiber reinforced polyamide-66.
After subacute or chronic treatment, these longer lived proteins may have higher quality and less damage; this is supported by our observation of lower levels of protein carbonyls (Fig. 4A) and a recent report that showed increased protein translation fidelity in RP-treated liver MEFs (Conn & Qian, 2013).
Provision of information and patient education about the objectives of treatment and the importance of changes in lifestyle, exercise, pacing of activities, weight reduction and other measures to unload damaged joints is supported by two meta-analyses [ 10, 11] on the efficacy of non-pharmacological interventions in chronic diseases.
In addition, the oxidative damage hypothesis, which is supported in the literature, suggests that CR itself achieves the same goal by decreasing oxidative stress [119, 120].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com