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Activation of the above-mentioned kinases following NEU damage is indicative of lesions, both DSBs and SSBs being formed on DNA.
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Our data indicate that expression of this gene in cardiac tissue increased with damage and is indicative of the observed pathophysiology (Figure 1H).
This type of DNA damage response is indicative of potential stalling of the replication fork or inhibition of replication fork elongation, and can be mediated during processing of bulky DNA lesions.
The distribution of impact damage and flaking is indicative of carefully controlled chipping of the broken edges in order to make them more regular (Figure 4).
If increased levels of foci and DSB damage in lymphocytes and adipose tissue is indicative of increased damage levels elsewhere, these findings provide a possible molecular mechanism by which obesity may lead to increased cancer risk.
Decreased fluorescence signal as percentage of total fluorescence (= 100%) was used as the level of endogenous DNA damage; thus a higher value is indicative of a higher amount of DNA damage, in the form of DNA strand breaks.
Evidence of genotoxicity has been previously researched within a number of studies; micronuclei development is associated with nano-TiO2 exposure, which is indicative of chromosomal damage; DNA damage has also been observed in response to nano-TiO2 exposure.
This indicates that propidium iodide had entered the cells and is indicative of damage to the cell membrane.
This was associated by clumping of neuronal processes (appearing as excess eosinophilia) which is indicative of damage to neurons.
As such, the reduction in pollen viability induced by this O3 fumigation is indicative of damage to the pollen membrane system.
The appearance in the circulation of the cardiac-specific isozyme of troponin is indicative of damage to the myocardium, and is associated with an adverse long-term prognosis [ 32].
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