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After the first damage hypothesis had been ruled out, two finite element models were built to compare the original design with the actually manufactured drum by means of nonlinear calculations.
The oxidative damage hypothesis proposes that SOD1's normal free radical scavenger role puts it at risk of oxidative damage and that it is this damage that triggers the misfolding primed by mutation.
The localization is performed by designing a bank of EKFs, in which each filter is tuned to a different damage hypothesis: i.e., in this case the specific crack location.
In addition, the oxidative damage hypothesis, which is supported in the literature, suggests that CR itself achieves the same goal by decreasing oxidative stress [119, 120].
The enhancement of antioxidant defenses and the resistance of depletion in lysozyme activity in the stressed D2 group compared to the stressed D1 group enables us to exclude the damage hypothesis.
The oxidative damage hypothesis proposed for the function gain of copper, zinc superoxide dismutase (SOD1) maintains that both mutant and wild-type (WT) SOD1 catalyze reactions with abnormal substrates that damage cellular components critical for viability of the affected cells.
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Both the incessant ovulation and oxido-reductive fallopian tube epithelial damage hypotheses have provided evidence that inflammatory responses induced under physiological conditions may foster the development of EOC.
There exist several proximate hypotheses for CR's effects at the cellular level, including the oxidative damage attenuation hypothesis [ 81- 83], altered glucose-insulin system hypothesis [ 84- 87], alteration of the growth hormone-IGF-1 axis hypothesis [ 88- 90], et cetera.
The second hypothesis, the "oxidative damage" theory, conjectures that toxicity is caused by the aberrant chemistry of the metal-binding sites of the mutant SOD1, such as peroxidase or superoxide-reducing activities and peroxynitrite catalysis.
A bridge damage detection hypothesis test is developed using girder distribution factors (GDF) under operational, output-only strain monitoring.
Furthermore, the linear damage accumulation hypothesis according to Palmgren and Miner is modified and improved to consider load sequence effects and non-linear behaviour.
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