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In cells subjected to replicative stress it is important to delay chromatin re-assembly until the DNA damage has been resolved, and one way to do this, would be to delay H3 modifications.
In such cases, p53 may engage antioxidant responses in order to decrease ROS levels or participate in DNA damage repair processes while inducing a transient cell-cycle arrest, thereby allowing cells to survive safely until the damage has been resolved.
Specifically, therapies that promote remyelination and prevent microglia activation, mitochondria dysfunction, and oxidative damage, while beneficial in relapsing-remitting MS, appear particularly crucial in treating patients with secondary progressive MS. It is also important to determine the exact role of inflammation during this phase to prevent relapse after tissue damage has been resolved.
Similar(57)
"It has been resolved".
Neither case has been resolved.
But that has been resolved.
But nothing has been resolved.
Shockingly, surprisingly little has been resolved.
Nothing has been resolved.
This issue has been resolved.
Update: This incident has been resolved.
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