But what makes "Mystic River" unusual is that the child molesters are dispatched early on and the remainder of the film explores the consequences for people who are not so much evil as profoundly damaged, culminating in a misplaced act of vigilantism that is unique in Mr. Eastwood's films.
Patients with severe haemophilia A (<1% FVIII C) experience frequent spontaneous haemorrhaging (bleeding) into soft tissue and joints, leading to debilitating joint damage, culminating in decreased quality of life 1– 3.
The generalized systemic immune activation that follows bloodstream invasion participates in the genesis of widespread endothelial injury and diffuse tissue damage, culminating in lethal septic shock [ 30, 31, 32].
In addition, the respiratory burst of innate immune responses also causes oxidative stress and DNA damage, culminating in greater genetic instability and apoptosis which hamper cellular proliferation for replacing damaged cells [ 24– 26].
Here, we investigated whether amyloid fibrils composed of A25T TTR, a natural variant of TTR that readily forms fibrils under non-denaturing conditions and is associated with OA, activate microglia and whether this activation leads to neuronal damage, culminating in cognitive deficits.
The failure of the Al polycrystals occurs by crack initiation at triple junctions and grain boundaries accompanied by localized shearing, leading to either trans- or intergranular cracks, while failure in the Al Si nanocomposites occurs by void damage accumulation, culminating in crack formation, at an Al/Si interface.
Ricin specifically depurinates A3027, while α-sarcin cleaves the phosphodiester backbone between A3027 and G3028, and both types of damage culminate in apoptosis.
These events could culminate in a vicious cycle of renal inflammation and monocyte infiltration, ultimately leading to permanent tissue damage.
